个人简介：胡方芝，副教授，1988年7月30日生，理学博士。国家级大学生创新训练指导教师。主持国家自然科学基金青年项目，主持企业委托项目1项，参与国家自然科学基金面上项目、山东省重点研发计划等4项课题；以第一作者或通讯作者身份在ACS Catalysis, Green Chemistry等国际著名SCI期刊发表论文12篇，ESI前1%高被引论文1篇；第一发明人身份授权发明专利3件。

所属学科：有机化学

研究方向：药物中间体及功能材料合成为导向的绿色合成方法开发。

教育与工作经历：

2023.01-至今    yl23411永利官网，副教授

2018.2-2022.12  yl23411永利官网，讲师

2014.9~2017.7  中科院成都有机所，博士，师从张晓梅研究员

2011.9~2014.7   四川大学，硕士，师从杜娟教授

2007.9~2011.7   临沂大学化学化工学院，学士，师从朱化雨教授

科学研究：

承担课题情况

1. 胺类化合物的β-位含氟基团官能化策略及其应用研究(22208184)，国家自然科学基金面上项目, 2023/01-2025/12，主持，30 万元；

2. 融合sp3碳氢键官能化过程的去芳香化反应构建手性稠杂环化合物(21978144)，国家自然科学基金面上项目, 2020/01-2023/12，第二位，65 万元；

3. 神经类药物米安色林及其类似物的高效合成新方法(2019GSF108020)，山东省重点研发计划，2019/01-2020/12，第二位，15 万元；

4. “经略海洋”战略背景下的药物创制研究(2019RKB01027)，山东省重点研发计划， 2019/12-2021/10，第三位，10 万元；

5. 海洋天然产物及药物仿生合成与应用(2019KJM002)，山东省高等学校优秀青年科技创新团队，2019/03-2022/03，参与，20 万元；

6. yL23411永利集团高层次人才启动基金(6631121010)，2022/07-2025/07，主持，6 万元。

代表性成果列表（工作以来第一作者发表）

21. Fangzhi Hu,∥ Jia-Wei Li,∥ Lindong Sun, Peng Wang, Dong Chu, Yao-Bin Shen,* and Shuai-Shuai Li, Green α,β-C(sp3)-H Difunctionalization of Saturated Cyclic Amines and Ethers through FeCl3Catalyzed Dehydrogenative [4 + 2] Cycloaddition under Air. Org. Lett. 2026, 10.1021/acs.orglett.6c01647.

20. Ye Xu,† Feng-Wei Guo,† Fangzhi Hu,† Mengya Li, Baohua Zhang, Xiang-Ping Kong, Wishwajith Kandegama, Jia-Cheng Ge, Fengyu Du*, Shuai-Shuai Li*, Design, Synthesis, and Bioactivity of Novel Ethyl 2‑Oxo-4-phenylbut-3-enoate Derivatives as Potential Herbicide Candidates. J. Agric. Food Chem. 2026, 74, 6640−6648. (中科院top一区，IF = 6.2)

19. Fangzhi Hu,† Peng Wang,† Jiawei Li, Fengying Dong, Long Yi Jin* and Shuai-Shuai Li*, Metal-free Cross-Dehydrogenative Coupling for α-Arylation of 3-Aryloxindoles, Chem Asian J. 2025, 20, e202500001. (中科院三区)

18. Lianyi Cao,† Shihai Yan,† Fangzhi Hu,† Fei Wang, Shuai-Shuai Li,* Mengzhe Pan, Yingkun Yan,* Xiao-Mei Zhang*, Hydride Transfer Enabled Dearomative Spirocyclization of Isoxazoles with O-alkyl ortho-Oxybenzaldehydes, Org. Lett. 2025, 27, 1835-1840. (中科院top一区)

17. Mengzhe Pan,‡ Feng-Wei Guo,‡ Xinjie Sun, Jie Zhang, Wei Lu, Lubin Xu, Fangzhi Hu* and Shuai-Shuai Li*, Divergent application of 5-amino-isoxazoles for the construction of nitrogen heterocycles via the hydride transfer strategy, Org. Chem. Front., 2025, 12, 1867–1873. (中科院一区)

16. Liang Wang,1Jing Wang,1 Xinyu Wang, Lubin Xu, Feng-Wei Guo, Xiong-Li Liu, Fangzhi Hu,* Shuai-Shuai Li*, Green solvent-controlled switchable synthesis of six-membered N-heterocycles and seven-membered O-heterocycles, Green Synthesis & Catalysis, 2024, GRESC310

15. Peng Wang,† Qiang Wang,† Meng Wang, Liang Wang, Lubin Xu, Xiong-Li Liu, Fangzhi Hu,* Shuai-Shuai Li*, Modular dehydrogenative cross-nucleophile coupling for direct construction of tetrasubstituted carbons, Org. Chem. Front. 2025, 12, 448–455 (中科院一区)

14. Jia-Cheng Ge, Yufeng Wang, Feng-Wei Guo, Xiangyun Kong, Fangzhi Hu,* Shuai-Shuai Li*, Dearomatization of 3-Aminophenols for Synthesis of Spi-ro[chromane-3,1'-cyclohexane]-2',4'-dien-6'-ones via Hydride Transfer Strategy-enabled [5+1] Annulations, Molecules 2024, 29, 1012 (中科院二区)

13. Ying Dong,§ Fangzhi Hu,§ Huixin Wu, Feng-Wei Guo, Liang Wang, Feng-Yu Du,* Shuai-Shuai Li*, Controllable Synthesis of N-Heterocycles via Hydride Trans-fer Strategy-enabled Formal [5+1] and [5+2] Cyclizations, Org. Lett. 2024, 26, 332–337 (IF = 5.2, 中科院top一区)

12. Zhipeng Sun,§ Ranran Hou,§ Shuai-Shuai Li,* Xinyu Wang, Liang Wang, Fangzhi Hu,* Feng-Wei Guo*, Controllable Synthesis of N-Containing and O-Containing Heterocycles via Formal [3+2] and [5+2] Cyclizations, Org. Lett. 2024, 26, 6–11. (IF = 5.2, 中科院top一区)

11. Fangzhi Hu, Zhipeng Sun, Mengzhe Pan, Liang Wang, Lubin Xu, Xiong-Li Liu, Shuai-Shuai Li*, Divergent synthesis of nitrogen heterocycles via H2O-mediated hydride transfer reactions, Green Chem. 2023, 25, 5134–5141. (IF = 9.8, 中科院top一区)

10. 陈玉琢†, 孙红梅†, 王 亮, 胡方芝*, 李帅帅*, 基于 α-氢迁移策略构建杂环骨架的研究进展, 有机化学, 2023, 43, 2323～2337. Invited Review

9. Yao-Bin Shen, Fangzhi Hu†, Shuai-Shuai Li*, Alkyl amines and ethers as traceless hydride donors in [1,5]-hydride transfer cascade reactions, Org. Biomol. Chem. 2023, 21, 700-714. Invited Review (IF = 3.89, 中科院三区)

8. Fangzhi Hu, Liang Wang, Peng Wang, Zhanshuai Ding, Yuzhuo Chen, LubinXu, Xiong-Li Liu, Shuai-Shuai Li*, Switchable construction of oxa-heterocycles with diverse ring sizes via chemoselective cyclization controlled by dibrominated compounds, Org. Chem. Front. 2022, 9, 6187-6193. (IF = 5.456, 中科院top一区)

7. Yao-Bin Shen,† Fangzhi Hu,† Shuai-Shuai Li*, Advances in α-C(sp3)–H functionalization of ethers via cascade [1,n]-hydride transfer/cyclization, Tetrahedron 2022, 127, 133089. Invited Review (IF = 2.388, 中科院三区)

6. Fangzhi Hu,† Yao-Bin Shen,† Liang Wang, Shuai-Shuai Li*, Merging dearomatization with redox-neutral C(sp3)–H functionalization via hydride transfer/cyclization: recent advances and perspectives, Org. Chem. Front. 2022, 9, 5041-5052. Invited Review (IF = 5.456, 中科院top一区)

5. Fangzhi Hu, Xinyao Li, Zhanshuai Ding, Liang Wang, Chunyan Ge, Lubin Xu, and Shuai-Shuai Li*, Divergent Synthesis of [3,4]-Fused 3‑Alkenyl-Oxindoles via Propargyl Alcohol-Triggered C(sp3)−H Functionalization, ACS Catal. 2022, 12, 943-952. (IF = 13.70, 中科院top一区)

4. Fangzhi Hu, Liang Wang, Chunyan Ge, Xinyao Li, Zhanshuai Ding, Lubin Xu, Shuai-Shuai Li*，Divergent α-Functionalization of Cyclic Amines via Ring Construction by Molecular O2 Oxidized Dearomatization and Ring Deconstruction by Aromatization Driven C-C σ-Bond Cleavage, Green Chem. 2021, 23, 5535–5541 (IF = 11.034, 中科院top一区)

3. Fangzhi Hu, Liang Wang, Lubin Xu and Shuai-Shuai Li*, Aromatization-driven Deconstruction/refunctionalization of Unstrained Rings, Org. Chem. Front. 2020, 7, 1570–1575. (IF = 5.456, 中科院top一区)

2. Xiaoyu Yang, Fangzhi Hu, Liang Wang, Lubin Xu and Shuai-Shuai Li*, Hydrogen-bonding-assisted redox-neutral construction of tetrahydroquinolines via hydride transfer, Org. Biomol. Chem. 2020, 18, 4267–4271. (IF = 3.876, 中科院三区)(共同一作)

1. Xintong Lv,# Fangzhi Hu,# Kang Duan, Shuai-Shuai Li*, Qing Liu, and Jian Xiao*, Aromatization-Driven Cascade [1,5]-Hydride Transfer/Spirocyclization Promoted by Fluorinated Alcohols, J. Org. Chem. 2019, 84, 1833-1844. (IF = 4.354, 中科院二区, 高被引论文) (共同一作)

授权发明专利：

1 一种3-烯基酮取代喹啉-2-酮及其绿色合成方法 胡方芝;王保桂;李帅帅;王鹏 ZL 2023 1 0090527.7

2 一种β-氨基酸衍生物活性骨架的绿色合成方法 胡方芝;李帅帅;王保桂;王鹏 ZL 2023 1 0095920.5

3 一种氧化吲哚螺烯丙基取代色满骨架及其制备方法 胡方芝;李帅帅;杜昭 ZL 2022 1 0933106.1

4 第三位获奖 氮杂环化合物的绿色精准合成 山东化学化工学会科学技术奖三等奖 SDSCCE-KJ2021-3-5

5 第三位获奖 惰性碳氢键精准官能化研究 山东化学化工学会科学技术奖二等奖 SDSCCE-ZR2024-2-7

本科教学指导学生等：

主讲《有机化学C》、《有机化学D》、《基础化学实验》等课程。所有讲授课程，学生评教皆为优秀。在2020年学院组织的青年教师讲课比赛中，获得学院二等奖。在2022年yL23411永利集团青年教师讲课比赛中，获得学校三等奖。积极指导大学生学术创新，指导国家级大学生创新训练项目1项，本科生校级创新训练3项。

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电话：18300200413