个人简介：刘志海，男，博士，教授，硕士生导师

研究方向：从事药学、中药学、微生物学方面的中药研发和细菌耐药性形成与防控技术研究 

学习工作经历：（从大学起，含博后、访学经历）

2025年11月至今：yL23411永利集团，yl23411永利官网，教授

2022年04月至2025年10月：yL23411永利集团，yl23411永利官网，副教授

2018年09月至2022年03月：yL23411永利集团，yl23411永利官网，讲师

2013年09月至2018年07月：中国农业大学（硕博连读），药理与毒理学，博士

2009年09月至2013年07月：山东农业大学，制药工程，工学学士

科学研究：

主持及参与课题情况

近几年先后主持细菌耐药性相关的国家自然科学基金面上项目、国家博士后科学基金、山东省青年科学基金 、山东省鲁渝科技协作计划项目子课题、校博士基金及企业横向课题等 10 项；参与国家自然科学基金重点项目、山东省重点研发计划、企业横向等课题 11 项；主持教研项目1项，参与1项。

代表性成果列表（近五年，按时间倒序排列）

目前已在Nat Microbiol、Adv Sci、J Hazard Mater、Environ Int、mBio、J Antimicrob Chemother、Antimicrob Agents Chemother等国际期刊发表科研论文近40篇；以一作或通讯作者发表SCI 论文近20篇；授权国家发明专利 4 项。近几年代表作如下：

1. Li X, Liu Z(并列一作), Wang J, Zhang Y, Tang H, Allardice PJ, Song Z, Qian B. Antibacterial activity of a nonmetal z-scheme heterojunction photocatalyst. J Photoch Photobio A. 2022:114019.

2. Liu Z, Wang K, Zhang Y, Xia L, Zhao L, Guo C, Liu X, Qin L, Hao Z. High prevalence and diversity characteristics of bla_NDM, mcr, and bla_ESBLS harboring multidrug-resistant Escherichia coli from chicken, pig, and cattle in China. Front Cell Infect Mi. 2022:1364.

3. Liu Z, Wang W, Zhang Z, Sun L, Wu S. Natural antibacterial and antivirulence alkaloids from macleaya cordata against methicillin-resistant Staphylococcus aureus. Front Pharmacol. 2022;13:813172.

4. Zhu X, Zhang Y, Shen Z, Wang W, Hao Z, Liu Z(通讯). Characterization of NDM-1-Producing Carbapenemase in Proteus mirabilis among broilers in China. Microorganisms. 2021;12:2443. DOI: 10.3390/microorganisms9122443.

5. Li W, Liu Z(并列一作), Yin W, Yang L, Qiao L, Song S, Ling Z, Zheng R, Wu C, Wang Y. MCR expression conferring varied fitness costs on host bacteria and affecting bacteria virulence. Antibiotics. 2021;10:872.

6. Liu Z, Guo C, Zhang Y, Zhao L, Hao Z. Rapid and sensitive detection of the colistin resistance gene mcr-3 by loop-mediated isothermal amplification and visual inspection. Microb Drug Resist. 2021;27:1328-1335.

7. Yin W, Ling Z, Dong Y, Qiao L, Shen Y, Liu Z, Wu Y, Li W, Zhang R, Walsh TR. Mobile colistin resistance enzyme mcr‐3 facilitates bacterial evasion of host phagocytosis. Adv Sci. 2021:2101336.

8. Fu Y, Chen Y, Liu D, Yang D, Liu Z, Wang Y, Wang J, Wang X, Xu X, Li X. Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms. J Hazard Mater. 2021;409:124921.

9. Guan N, Liu Z(并列一作), Zhao Y, Li Q, Wang Y. Engineered biomaterial strategies for controlling growth factors in tissue engineering. Drug Deliv. 2020;27:1438-1451.

10. Zhai R, Fu B, Shi X, Sun C, Liu Z, Wang S, Shen Z, Walsh TR, Cai C, Wang Y. Contaminated in-house environment contributes to the persistence and transmission of NDM-producing bacteria in a Chinese poultry farm. Environ Int. 2020;139:105715.

11. Liu Z, Ma C, Gao H, Huang X, Zhang Y, Liu C, Hou R, Zhang Q, Li Q. A polysaccharide from Salviae miltiorrhizae radix inhibits weight gain of mice with high‐fat diet via modulating intestinal bacteria. J Sci Food Agr. 2024;104:479-487.

12. Liu Z, Li K, Wang Q, Liu C, Wang B, Hou R, Diao Y, Wang J, Du X, Qu L. Isotopic internal standard correction for the determination of diludine residue in animal-derived matrix samples using enhanced matrix removal-lipid clean-up combined with ultra-performance liquid chromatography-tandem mass spectrometry. Microchem J. 2023;195:109395.

13. Qu L, Zhu F, Han Q, Chen G, Liu Y, Li Y, Lei C, Zhan C, Liu Y, Du X, Liu Z. Characterization of Mylabris cichorii, Epicauta aptera, and Huechys sanguinea by morphological examination, DNA barcoding identification and chromatography analysis methods. Microchem J. 2025:115899.

教学授课情况：主讲《生药学》、《药用植物学》、《中药学》、《药用植物学与生药学》等本科生课程以及《现代仪器认知与实践》、《高等制药工程》研究生课程

获奖及社会兼职等情况：中国畜牧兽医学会兽医药理与毒理学分会理事，福建省科技特派员，青岛市科技特派员等

已培养研究生情况：已培养（包括联培）8名

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